Volume-1 Issue-1

Therapeutic management of gliosarcoma in the stupp protocol and temozolomide era


Gliosarcoma (GSM) is a rare malignant brain tumor which ac- counts for 1-8% of all malignant glioma [4]. GSM is a type of glioma grade IV with a biphasic tissue pattern, alternating ar- eas displaying glial and mesenchymal differentiation Even if GSM and glioblastoma (GBM) share some common features, they are different histological entities and should be con- sidered separately also from a therapeutical and prognostic point of view.
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Bariatric Surgeries and Liposuction are not Risk-free nor Magic


Surgical practice represents an important field of modern medicine. It has allowed to save lives, cure diseases that were without a positive outcome and open novel doors.
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Comparative antimicrobial efficacy of 2% chlorhexidine and Cupral paste along with electrophoresis in the apical region of root canals obstructed with a fractured instrument


Procedural errors commonly occur during endodontic treat- ment. Instrument fracture in the root canal system is a com- mon procedural error that can compromise the outcome of endodontic treatment if not properly managed.
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A review of high glycemic index (gi) in relation to risk of parkinson’s disease


Parkinson’s disease (PD) is the most common neurodegenerative disorders with a worldwide prevalence in the millions . The frequency increases with age, affecting 1% of the population over the age of 60.
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Wide excision of eyelid tarsus with superficial lamellar lid margin tarsus excision for palpebral conjunctival melanoma


Non-bulbar conjunctival melanoma is associated with poor prognosis especially in the Chinese population. The wide excision with external lamellar lid margin tarsus sparing was a simple approach that yielded good cosmetic outcome and desirable disease control.
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A case of Hepatocellular Carcinoma in Abernethy syndrome


A 47-year-old man presented to a district general hospital with upper abdominal pain. Ultrasound of the abdomen showed an indeterminate mass in the right lobe of the liver with no sign of intrahepatic biliary dilation. His blood results revealed a raised alkaline phosphatase (286 U/L), raised alanine aminotransferase (158 IU/L) and a raised bilirubin (25 mg/dL).
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Severe tricuspid regurgitation as first manifestation of a primary ovarian carcinoid tumor


Carcinoid tumors are neuroendocrine malignancies that can release serotonin and other vasoactive peptides into the systemic circulation. These substances are thought to cause the carcinoid syndrome, which is characterized by episodes of vasomotor changes (flushing, hypo-or hypertension), diarrhea, bronchospasm or carcinoid heart disease.
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Peri-Caecal internal hernia: A case report and review of the literature


Internal hernias are defined as the protrusion of a viscera through a normal or abnormal orifice whose location is peritoneal or mesenteric. Their incidence in large autopsy series varies between 0.2 and 2%. We report here, the case of a pericaecal internal hernia discovered in a context of intestinal obstruction.
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Paravertebral hydatid cyst: A rare case report


Hydatidosis is a common disease in cattle-raising areas and which caused by the Echinococcus Granulosus. This tapeworm infestation leads to cysts formation in live stocks. Canids are definitive hosts and human could be an intermediate and accidental host.
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Granulocytic Sarcoma with unusual localizations (breast and stomach) without Bone Marrow involvement after the Allogeneic Transplantation


Granulocytic sarcoma is a rare extramedullary solid tumor composed of immature myeloid cell and is associated with acute myeloid leukemia or myelodysplastic syndrome. It was first reported by Burns in 1811 and was described as chloroma by King in 1853.
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Biopolymer pneumonitis a differential diagnosis in covid-19 era: A case report and review of the literature


Biopolymers are substances with inherent characteristics of biocompatibility and biodegradation that make them useful in the biomedical, pharmaceutical, environmental, biocatalytic and bioelectronic fields.
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HIV client’s satisfaction with home delivery of antiretrovirals in Abuja, Federal Capital Territory, Nigeria: A pilot study


Over the past decades, highly active antiretroviral therapy (HAART), has transformed human immunodeficiency virus (HIV) infection from being a deadly disease to a chronic illness. This is possible because effective management allows an infected individual to survive till old age resulting in a large number of stable patients on HAART
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Follow-up strategies in focal liver lesions and treatment methods


Most incidental lesions are benign, some may require careful management and treatment. In evaluating the lesion, the patient’s clinical history, underlying disease and age factor should be considered.
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Early leakage of peritoneal effluent to subcutaneous tissue after a sneeze


Human norovirus, previously known as the Norwalk virus was the first virus that was identified as causing gastroenteritis in humans. Although norovirus gastroenteritis is generally mild and of short duration, new evidence suggests that the illness can be severe and sometimes fatal, especially among vulnerable populations-young children and the elderly and is a common cause of hospitalization for gastroenteritis.
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Liver Dysfunction in Norovirus Gastroenteritis in a Child with Cerebral Palsy: A Case Report


Human norovirus, previously known as the Norwalk virus was the first virus that was identified as causing gastroenteritis in humans. Although norovirus gastroenteritis is generally mild and of short duration, new evidence suggests that the illness can be severe and sometimes fatal, especially among vulnerable populations-young children and the elderly and is a common cause of hospitalization for gastroenteritis.
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Lightning injuries: same incident, different injuries - A case series


Lightning is a spectacular weather phenomenon. It has caused countless injuries to humans and considerable damages to properties. Singapore, lying near the Equator, has one of the highest lightning activities in the world.
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Polyclonal hypergammaglobulinemia in HIV infected patient case report and review of the literature


The most common plasma cell disorders reported in patients with HIV infection or AIDS are polyclonal hypergammaglobulinemia, monoclonal gammopathy and symptomatic multiple myeloma.
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Extraskeletal myxoid chondrosarcoma involving the jugular foramen and cerebellopontine angle: a case report


Lesions extending to or developing from the jugular foramen are uncommon. The most frequent tumor of the jugular foramen – paraganglioma, or glomus tumor, has a reported incidence of 1 in 1.3 million.
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A rare case of azygos vein arch aneurysm: A case report


The aneurysm of the azygos vein (AVA) is a very rare pathology, with almost 50 cases in literature, mostly with a fusiform shape and identified in people between 19 and 70 years old. Since azygos vein (AV), normally, has a diameter of about 1cm, we define “aneurysm” a dilatation over 1,5cm.
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Dancing swan in left hemithorax


A 67-yrs-old, diabatic,hypertensive individual was admitted for multivessel coronary artery bypass graft surgery . Off-Pump CABG was performed using Left Internal Thoracic Artery to Left Anterior Descending Artery, left radial artery to first Obtuse Marginal branch, and reversed saphenous vein graft to Posterior Descending Artery as conduits.
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Prognostic factors of the overall survival and disease progression in advanced non-small cell lung cancer patients in India: Mini review


Lung cancer is the most prevalent cancer among females and males, carrying the highest cancer-related mortality rates worldwide. Nearly two-thirds of patients present in the advanced stage at diagnosis requiring palliative therapy with chemotherapy and often radiotherapy, giving a variable response, too. Knowledge of prognostic factors might guide in tailoring the therapy in resource-limited countries. Hence, we reviewed the prognostic factors affecting overall survival and disease progression in advanced non-small-cell lung cancer patients.
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Histomorphological effects of daucurs carota extract on dispirin induced kidney damage in albino rats


This study was carried out to investigate the protective effect of extract against dispirin induced renal toxicity in albino rats. The histological effect of consumption of Daucurs carota root extract on the kidney of albino rats was carried out. The albino rats were divided into five groups. Each group consists of 5 albino rats.
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Hepato-Cutaneous Fistula: A rare delayed complication after healed Pyogenic Liver Abscess


Hepato-cutaneous fistula is a rare clinical entity which develops commonly after a complication due to hydatid disease of the liver. Few cases of it have also been reported following percutaneous catheter drainage of liver abscess due to actinomyces, burkholderia pseudomallei and entamoeba histolytica. In case of hydatid cyst of liver, it develops following spontaneous rupture or some intervention.
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Case Series of Pectoral Hematoma Associated with Enoxaparin Use in Elderly Patients


Venous thromboembolism is among the common and preventable cardiovascular syndromes. The risk of thromboembolism is increased in elderly and patients with renal failure, and the risk of bleeding due to the use of anticoagulants also increases. In these cases enoxaparin use for profilactic and treatment dosages. After anticoagulant using pectoral hematoma was diagnosed by ultrasonography and computed tomography of the thorax in patients.
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Brain imaging abnormalities in cerebral palsy


Cerebral palsy is a group of heterogeneous disorders caused by an abnormal development or brain damage affecting mostly regions controlling movements, balance, and posture. The brain damage and abnormalities in cerebral palsy are characteristically non-progressive, but lead to permanent abnormalities of movements, posture, and limitation of mobility. Many systems are available.
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Personal Digital Health Assistants


Personal Digital Health Assistants (PDHA) are applications that can run on a computer or mobile device. They acquires, stores, and analyzes health information and communicate with remote servers. They are utilized by patients or their caregivers. Many systems are available.
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Antimicrobial photodynamic therapy as an adjunctive therapy in dentistry


Oral health is an important factor in maintaining general well-being. Dental caries, endodontic, and periodontal diseases can affect oral soft and hard tissues in the oral cavity. Due to traditional chemo- mechanical method risks in dentistry, antimicrobial photodynamic therapy (aPDT) as an interesting therapeutic approach has been developed. This review focused on the role of aPDT as an adjunctive therapy in dentistry.
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Bilateral Staged Ureteral Stenosis Secondary to Wegener’s Disease: A Case report


Wegener’s disease is a rare vasculitis characterized by inflammation of the endometrium of blood vessels. Ureteral stenosis is a rare manifestation of granulomatosis with polyangiitis (formerly known as Wegener’s granulomatosis). We report the case of a 38-year-old woman with acute renal failure in which bilateral hydronephrosis due to staged ureteral stenosis was the second manifestation of the disease after necrotico-inflammatory skin lesions. Our patient had high titers of anti-proteinase 3 c-ANCA, but no upper or lower respiratory tract damage was demonstrated.
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Mucinous Adenocarcinoma Arising from Chronic Perianal Fistula - A Case report


Mucinous adenocarcinoma arising from chronic perianal fistula in ano is a rare entity. It is often mismanaged as benign disease due to its presentation. At present no guidelines have been established concerning diagnostic and treatment strategies due to the rarity of the tumour.A high index of clinical suspicion and biopsy of fistulous tracts and abscesses are key to early diagnosis and prompt treatment.
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Assessing undernutrition of trauma patients with complex soft tissue defects treated at viet duc university hospital using prealbumin serum levels


Wound care is an important part of treatment for surgical patients. Wound healing complications such as infection, delayed healing affecting the treatment process, causing prolonged hospital stay, increasing costs. According to a statistic in the US, the length of hospital stays increasing with an average of 7.4 days due to complications related to wound care cost an additional 130 million USD per year.
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Analysis of the curative effect of laparoscopic primary suture of common bile duct with two choledocholithotomy routes


At present, laparoscopic surgery combined with endoscopy is the first choice for the treatment of biliary calculi. In the treatment of extrahepatic bile duct stones, the common bile duct can be sutured at the same time of cholecystectomy. Laparoscopic cholecystectomy is rapidly replacing traditional cholecystectomy as the treatment of choice for patients with cholelithiasis, in this study author's team has accumulated a large number of cases and rich surgical experiences since carrying out laparoscopic common bile duct primary suture in the treatment of extrahepatic bile duct stones.
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Chronic inflammatory bowel disease and demyelination of the central nervous system: A report on 2 cases


We report the clinical history of a 45-year-old patient, followed up for 12 years for Crohn's disease. The patient was initially treated with sulfasalazine during the first two years of the disease and then, following an exacerbation of the disease, with azathioprine 100mg/d and prednisolone 80mg/d.
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A retrospective study on how Residual Fibromyalgia Syndrome is affecting the functional capacity of patients with COVID-19


Over the last several months, the U.S. healthcare system has challenged the consequences of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak. After the acute phase of the disease, patients return to our clinic reporting ongoing symptoms such as: chest pain, back pain, fatigue, myalgias, cough, post-nasal drip, shortness of breath, sleep fragmentation, memory loss, anxiety, and depression.
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Toddler’s fracture: False positive radiologic considerations


Fracture of the tibia is a well-known, often occult cause of limping and leg pain in young children following a low energy trauma and twisting injury. This fracture which is typically known as “Toddler’s fracture” forms a hairline, oblique fracture in the shaft of tibia. The diagnosis of a Toddler’s fracture could be puzzling at the time of presentation as the history of trauma is often vague, the physical examination of the limping child is mostly inconclusive and the radiological evidence may be subtle.
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A fairly diffuse and extensive pancreatic calcification


A 37-year-old male presented with worsening epigastric pain and nausea for one-week. Past medical history was significant of alcoholic chronic pancreatitis and gallbladder stones disease status post-cholecystectomy seven years ago. Physical examination revealed focal epigastric tenderness.
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Multimodal imaging modalities in acute Vogt-Koyanagi-harada disease


Vogt-Koyanagi-Harada disease (VKH) is a severe bilateral granulomatous posterior or panuveitis. An acute case of VKH presents with gradual painful diminution of vision which may be associated with symptoms like tinnitus, hearing loss, vertigo, meningismus, poliosis, and vitiligo, although not all patients present with the complete constellation of these extra-ocular findings.
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Loratadine syrup is successfully used to fix COVID-19 induced respiratory distress and chest pain


COVID-19 disease is a highly transmissible viral infection caused by the SARS-CoV-2 coronavirus. This virus is closely related to the SARS-CoV and MERS-CoV coronaviruses. All three viruses can cause lung damage, acute respiratory distress syndrome and death. Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus , that was first recognized in Wuhan, China, in December 2019.
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Medical teacher’s appraisal: New challenge for European family medicine teachers


A professional appraisal can be defined as the process whereby an appraiser examines and evaluates an appraisee’s work by comparing it with pre-set standards. This process is generally designed to encourage the professional to reflect on his or her work and to provide evidence that the required standards are being achieved.
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Controlled ovarian hyperstimulation (COH) with sequential hpfsh & hmg versus rec-F.S.H alone in ICSI cycle


The aim of this work is to investigate the sequential use of hpFSH+hHMG vs. rFSH alone on fertility out- come (rate of gestation, abortions and live delivery) in ICSI-cases.
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The Current State Of Diagnostics For Cystic Formations Of The Neck: A Literature Review.


Modern literature data indicate that among the various possible cystic formations that form in the neck, the most frequently studied are median and lateral cysts. It was found that multimodal radiation diagnostics of cystic formations of the neck using ultrasound and magnetic resonance imaging significantly increased the efficiency of the examination.
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Molecular-Genetic Features In The Diagnosis Of Odontogenic Tumors


Benign odontogenic formations cause one and the same controversial situation known to pathologists for the last century. Some researchers believe that they are indeed benign. These formations are often asymptomatic, and the X-ray picture is not always reliable. There are currently no clear criteria for predicting the development of relapse.
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Intermittent Fasting and Gut Microbiota


Fasting is an age-old practice done by avoidance of intake of solid or liquid edibles for a certain period of time. This has been practiced for a number of reasons such as dieting, religious ways and also in medical field for lab investigations such as measurement of blood glucose and lipid markers, pre- and post-surgical indications.
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Alpha2- Adrenergic blockers restore noise-induced biochemical and cognitive disorders


Noise-induced stress causes central nervous system dysfunction and neurotransmission impairment in the brain and changes hormone levels which potentially result in psychological and behavioral problems.
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Goldberg Shprintzen syndrome: The novel association with congenital unilateral anorchia (monorchism)


Goldberg Shprintzen syndrome is a very rare autosomal recessive mental-growth retardation syndrome associated with characteristic facial dysmorphism, Hirschsprung disease, and a variety of neurological abnormalities, and abnormalities on brain imaging studies.
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Thyroglossal duct cyst: About a case and review of the literature


The thyroglossal duct cyst (TDC) is the most common congenital cervical malformation [1,2,3]. Indeed,embryologically, the thyroid originates at the level of the foramen cecum, at the base of the tongue
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Detecting the presence of grp-78 gene in syrian strain of leishmania tropica genome and sequencing it


Leishmania tropica is the main cause of cutaneous leishmaniasis which represents a common issue in Syria. After the start of the current war, cutaneous leishmaniasis has become yet more widespread, so an effective vaccine is needed to prevent a largescale spread of leishmania in the country

Anesthetic management in a patient with steinert syndrome undergoing laparoscopic cholecystectomy: A case report


Steinert Syndrome (SS) is a progressive, hereditary, multisystem muscular dystrophy. We aim to describe the anesthetic management of a patient with SS undergoing laparoscopic cholecystectomy (LC).
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Ulcerated inguinal lymph node metastases in vulvar cancer


A 75-year-old patient presented with anorexia, weight loss, dyschezia and dysuria. She had fever for one week. Physical examination revealed an abscess draining from the left groin
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Huge primary vaginal stone protruding through vaginal orifice damaging the hymen and associated with vesicovaginal fistula and urinary bladder stone: Case Report


We reported a case of 29 years old single lady presented with continuous urine leak for more than one year. Ultrasound study (USS) showed urinary bladder (UB) stone.

Endobronchial intubation in tracheal stenosis: An uncommonly reported complication


Tracheal stenosis is a life-threatening condition resulting from various causes like congenital, postintubation injury, trauma, inhalational burns, irradiation, tracheal tumor, extrinsic compression of trachea by tumor and idiopathic

Abdominal wall endometrioma: Case report


We report a case of endometrioid pattern adenocarcinoma of the abdominal wall. The patient was submitted to exploratory laparotomy with resection of the tumor in the abdominal wall besides extended hysterectomy, umbilical herniorrhaphy and cholecystectomy

Retrospective analysis of the Prevalence of Oral Potentially Malignant Disorders and Oral Cancer in a hospital-based Setting during the COVID-19 Pandemic


The Coronavirus pandemic have wreaked havoc on health systems worldwide. Due to lockdowns imposed all across the globe, patients have been unable to show up to dental institutions for regular dental check-ups.

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