Cancer is one of the illnesses where the stage at which the disease is diagnosed plays a crucial role patients survival and quality of life . A diagnostic indicator that can detect cancer in early stages is of great significance, especially for breast cancer (BC), as it is the most common cancer in woman . One field of interested is that of tumor markers, due to their noninvasive, rapid and simple nature . Despite their low sensitivity and specificity, the carcinoembryogenic antigen (CEA) and cancer antigen 153 (CA153) are the commonest markers used.
Cardiac tamponade is a life-threatening condition characterized by the accumulation of fluid, blood, pus, clots, or even gas within the pericardium which compromise of cardiac function. It can occur due to various causes such as inflammation, trauma, heart rupture, aortic dissection. Recently it has become increasingly common as a complication of complex cardiac interventions usually caused by epicardial artery rupture. In this case, we present a patient who developed delayed cardiac tamponade following percutaneous coronary intervention, with no apparent cause identified despite extensive investigation using imaging methods. After antiplatelet therapy de-escalation pericardial bleeding in ceased and patient had survived with full recovery.
Ibrutinib is a small-molecule drug approved for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom macroglobulinemia. Although it has been connected to ocular side effects, few clinical cases explain cystoid macular oedema associated with long-term Ibrutinib treatment. A case of Cystoid Macular Oedema (CMO) caused by ibrutinib in a patient with chronic lymphocytic leukemia is presented. In our case study, an 85-year-old man’s vision deteriorated over 6-7 months. His right eye’s presenting vision was 0.76 and his left eye was 0.2. There was bilateral macular oedema on inspection. His ibrutinib treatment lasted 12 months. The temporal correlation between ibrutinib treatment modifications and the ocular inflammation in our patient points to a causal relationship. Ibrutinib is thought to cause drug-induced cystoid macular oedema.
We report a case of a 33-year-old woman, who complains of a progressive loss of visual acuity for 6 years. Visual acuity was 4/10 which cannot be improved in both of eyes. The examination of the anterior segment of both of eyes was normal. Fundus examination reveals the existence of a rounded yellowish macular lesion with major macular atrophy in both of eyes (Panel A and B), the peripheral retina was normal. Auto fluorescence picture describe a bull’s-eye maculopathy limited by a hyperautofluorescent ring (Panel C). Macular OCT shows loss of the outer segments of the foveal photoreceptors (Panel D). The electroretinography confirmed the diagnosis of cone dystrophy by demonstrating an absence of response under photopic conditions, while the scotopic response is preserved.
Analysis of erg 11 expression in clinical isolates of dermatophytes in patients with resistant tinea infection
Dermatophytes, a group of keratinophilic filamentous fungi thriving on the keratin substrate, are the etiological agents responsible for causing superficial fungal infection in human and animals with an estimated global prevalence of approximately 20 percent as per the World Health Organization (WHO) report. Predominant in the tropical and subtropical countries; especially in the developing countries like India, the hot and humid climate is favorable to the acquisition and maintenance of the disease .
Cerebral stroke, also known as “stroke” and “cerebrovascular accident”, is an acute cerebrovascular disease, including ischemic and hemorrhagic stroke. Cerebral stroke is the first cause of death and adult disability among Chinese residents , characterized by high incidence, high mortality, high disability and high recurrence . Recent studies have found that intestinal flora may affect the occurrence and development of cerebral stroke through various channels such as nervous, neuroendocrine, and immune systems . The immune and inflammatory responses of cerebral stroke patients continue to participate in the whole process of brain tissue injury and repair. As the largest immune system, the digestive tract plays an important role in regulating the immune function of the body .
Foreign body placement in the urethra has always been alluring to urologists, and is an uncommon urological emergency. Wide varieties of foreign bodies have been encountered and reported in the literature including electrical wires, batteries, beans, sharp tiny objects and other tools, mostly in male adult population although there are reported cases in the pediatric population as well. Many causes have been linked to such presentations which range from sexual gratification, psychiatric mental illness, masturbation curiosity etc.