Nitroglycerin (NTG) is an ancient commonly prescribed short-acting anti-anginal agent [1]. Nitrates produce vasodilation with predominant venous effects on large capacitance vessels. They also increase coronary collateral circulation, increase aortic compliance, and conductance and blood flow to ischemic areas of the myocardium. Besides, nitrates alleviate anginal symptoms by directly influencing the coronary arteries, coronary collateral circulation, aortic compliance and conductance, and blood flow to ischemic areas of the myocardium [2]. Short-acting nitrates are beneficial in acute ischemic heart disease (IHD) and hypertensive crises [3]. Although NTG is a clinically effective therapy in this condition, its exact mechanism of action is still uncertain [4]. However, NTG may suppress the incidence of premature ventricular complexes (PVCs) in acute ischemic attack [5]. Nitroglycerin administration was associated with a significantly more rapid reduction in ventricular arrhythmias: 6 hours after onset of recording, the number of PVCs had declined to 39% of the baseline value [6]. PVCs are described as premature and bizarre-shaped QRS-complexes that are unordinary long (typically >120 msec) and seem wide on the ECG. The QRS-complexes are not forwarded by a P-wave, and the T-wave is usually large and directed in the opposite of the major deflection of the QRS [7]. PVC is a type of arrhythmia characterized by premature heart contractions arising in one of the ventricles [8]. PVCs are early depolarization of the myocardium emerging in the ventricle [8] due to an electrical impulse or ectopic rhythm from any part of the ventricles before the sinoatrial impulse has reached the ventricles [8]. Whatever, PVCs in absent structural heart disease (SHD) is not harmful if there is no risk factors [9]. Indeed, PVCs with SHD are considered a way to sudden cardiac death (SCD) [9]. Unfortunately, more-frequency PVCs carry a poor prognosis [9]. Multifocal and multiform PVCs are considered red flags and risk markers for SCD [9]. The presence of PVCs in patients of IHD is associated with a poor prognosis [9]. However, PVCs with established IHD may be viewed as a marker of disease severity or as an endpoint in the natural history of the disease process [9]. The presence of PVCs in patients of IHD is associated with a poor prognosis [9]. An according to the Joint National Committee (JNC 7-2003) for prevention, detection, evaluation, and treatment of high blood pressure, the hypertensive crisis is defined as the elevation of systolic blood pressure (SBP) >179 mmHg or diastolic blood pressure (DBP) >109 mmHg [10]. Moreover, hypertensive crises can be classified into hypertensive emergencies or hypertensive urgencies depending on the presence or absence of acute end-organ damage, particularly [11]. The most common presentations in hypertensive urgency are headache (22%) and chest pain (27%) followed by dyspnea (22%) in hypertensive emergencies [12]. End-organ damage can be defined as the acute damage and resulting dysfunction of the eyes (retinal hemorrhages, exudates, or papilledema), the brain (hypertensive encephalopathy), the heart (acute pulmonary edema), or the kidneys (acute renal failure). This differentiation is an extremely useful issue for clinical, management decisions, and prognostic effect on morbidity and mortality. Importantly, in hypertensive urgencies, the blood pressure should be reduced within 24-48 hours, whilst hypertensive emergencies require immediate blood pressure reduction to prevent irreversible end-organ damage [11]. PR interval measured from the standard electrocardiogram (ECG) indicates the time from the beginning of atrial depolarization to the start of ventricular depolarization [13]. Prolonged PR-interval or first-degree heart block in ECG is defined by PR-interval >200 ms. In most cases, it is due to delayed conduction in the AV node, although conduction delay in the atrium, the His-Purkinje system, or multiple sites may also share in the prolonged PR-interval [13]. Historically, prolonged PR-interval or first-degree heart block conventionally was considered as a benign ECG finding in healthy individuals. But recent studies have proposed that it may be accompanied by rising of both mortality and morbidity [14].