It is important to study the anatomy of the median nerve in order to comprehend how the Hand of Benediction and median neuropathy are related. The median nerve is a major peripheral nerve in the upper limb, originating from the brachial plexus and extending down the arm. The median nerve, commonly known as the "eye of the hand," is a mixed nerve that plays a crucial part in the daily functioning of the hand [1]. It controls the abduction of the thumb, flexion of the hand at the wrist, and flexion of the digital phalanx of the fingers by innervating the group of flexor-pronator muscles in the forearm and the majority of the musculature found in the radial region of the hand. The median nerve allows the palmer face of the thumb, the index, middle, and radial sides of the ring finger, as well as the entire palmar region of the radial half of the hand, to receive sensory innervation. It gives the thumb, index finger, middle finger, and half of the ring finger sensation and motor control. The Hand of Benediction and Median Neuropathy: The term "median neuropathy" refers to the compression or injury of the median nerve, which causes functional limitations and distinctive clinical signs [2]. Pain, numbness, and weakness in the hand and fingers, especially the thumb, index, and middle fingers is present.

The Hand of Benediction is one unique indication of median neuropathy at the forearm or elbow [3]. The inability of the thumb, index, and middle fingers to bend at the metacarpophalangeal joints when trying to make a fist is what distinguishes this physical finding. The distal interphalangeal joint (DIP) and proximal interphalangeal joint (PIP) of the index finger do not flex, giving the appearance of a pointed finger These fingers, however, remain extended, imitating the hand motion used to express blessings. This problem happens as a result of an imbalance in finger flexion and extension caused by the paralysis or weakening of the muscles regulated by the median nerve. Diagnosis and Clinical Importance: When evaluating patients who appear with hand and wrist diseases, the Hand of Benediction sign must be present. Examining it might help doctors diagnose median neuropathy and distinguish it from other illnesses that might present with similar symptoms